Lawrence Lustig MD, former President of AOS, delivered the Howard P. House Memorial Lecture for Advances in Otology at the annual AAO-HNSF meeting this past September. Dr. Lustig described his seminal work in pioneering gene therapy for genetic forms of hearing loss and provided an update on current clinical trials focused on recovering otoferlin gene function. Dr. Lustig’s insights on gene therapy for hearing loss can be found at DOI: 10.1097/MOO.0000000000001070.